WWP1抗原，WW结构域E3泛素连接酶1抗原

Recombinant human WWP1   

AIP 5; AIP5; Atropin-1-interacting protein 5; hSDRP1; nedd4 like; NEDD4-like E3 ubiquitin-protein ligase WWP1; Tiul1; WW domain containing E3 ubiquitin protein ligase 1; WW domain-containing protein 1; WWP 1; WWP1_HUMAN.          

浓度：1mg/ ml

来源：Recombinant Human

纯度：≥95% SDS-PAGE

表达系统：Escherichia coli

标签：His tag   

蛋白长度：Full length protein

内毒素水平：<1.000 Eu/µg

纯化方法：HPLC

应用：SDS-PAGE，Western blot，ELISA

Biological activity,immunology research

保存：-20℃

保质期：1年

WWP1 is an E3 ubiquitin ligase and belongs to a family of NEDD4-like proteins. WWP1 contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. The HECT domain of WWP1 has been implicated in regulating the localization and stability of p53 – inhibition of WWP1 results in a decrease in p53 expression, whilst WWP1 mediated stabilization of p53 appears to be associated with an accumulation of cytoplasmic p53. WWP1 also negatively regulates the TGF beta tumor suppressor pathway by inactivating its molecular components (SMAD2, SMAD4 and TGFbetaR1). WWP1 has been implicated in both breast and prostate cancers.

多克隆抗体

产品名称：Rabbit Anti-WWP1 antibody

Rabbit Anti-WWP1 

别名：AIP 5; AIP5; Atropin-1-interacting protein 5; hSDRP1; nedd4 like; NEDD4-like E3 ubiquitin-protein ligase WWP1; Tiul1; WW domain containing E3 ubiquitin protein ligase 1; WW domain-containing protein 1; WWP 1; WWP1_HUMAN.             

来源：Rabbit

克隆类型：Polyclonal

浓度：1mg/ml

亚型：IgG

反应：Rat (predicted: Human,Mouse,Rabbit,Sheep,Cow,Dog,Horse)

应用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500

理论分子量：105kDa

免疫原：KLH conjugated synthetic peptide derived from human WWP1

保存：-20℃
保质期：1年

 单克隆抗体

产品名称：Anti-WWP1 antibody

Mouse Anti-WWP1

别名：AIP 5; AIP5; Atropin-1-interacting protein 5; hSDRP1; nedd4 like; NEDD4-like E3 ubiquitin-protein ligase WWP1; Tiul1; WW domain containing E3 ubiquitin protein ligase 1; WW domain-containing protein 1; WWP 1; WWP1_HUMAN.                

来源：Mouse

克隆类型：Monoclonal

浓度：1mg/ml

亚型：IgG

反应：Human

应用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500  

反应:  Human

理论分子量：105kDa

免疫原：KLH conjugated synthetic peptide derived from human WWP1

保存：-20℃
保质期：1年

WWP1 is an E3 ubiquitin ligase and belongs to a family of NEDD4-like proteins. WWP1 contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. The HECT domain of WWP1 has been implicated in regulating the localization and stability of p53 – inhibition of WWP1 results in a decrease in p53 expression, whilst WWP1 mediated stabilization of p53 appears to be associated with an accumulation of cytoplasmic p53. WWP1 also negatively regulates the TGF beta tumor suppressor pathway by inactivating its molecular components (SMAD2, SMAD4 and TGFbetaR1). WWP1 has been implicated in both breast and prostate cancers.